Endocrine Abstracts

Introduction: The prevalence of abnormal liver function tests (LFTs) in the general population has been estimated to be 8.1–9.8%. Abnormal LFTs are common in diabetes although there are still few studies describing the exact prevalence. AST-to-platelet-ratio-index (APRI) and Fibrosis-4-score (FIB4) are scoring systems which can be used to estimate the degree of liver fibrosis. An APRI score >1 has a sensitivity of 76% and a specificity of 72% for predicting cirrhosis ...

Introduction: Combination therapy using pegvisomant and cabergoline with first-generation long-acting somatostatin analogs (1GSSA) is a common procedure in acromegalic patients that are not fully controlled by surgery and 1GSSA. Pasireotide-LAR is a new multireceptor-targeted somatostatin receptor ligand that has superior efficacy over octreotide LAR to control GH and IGF1 levels. Little data is available about the efficacy and safety of pasireotide monotherapy in patients tre...

Craniopharyngiomas are rare and histologically benign tumors that are associated with an unfavourable prognosis and controversial optimal treatment. The aim of this retrospective study was to review clinical presentation, natural history and therapeutic outcomes of patients with craniopharyngiomas treated in a single center between 1995 and 2017. In that period, 38 patients (16 children and 22 adults) were diagnosed with craniopharyngioma. Median age at the time of diagnosis i...

The recently (2015) revised American Thyroid Association guidelines for the management of differentiated thyroid cancer recognise the importance of histological subtype in risk stratification. The prevalence of thyroid cancer subtypes in an Irish population is unknown. We reviewed all histology reports of thyroid carcinoma from a quaternary referral centre over a 10 year period, 2005 to 2015. 675 reports were reviewed. Of these, 87% were reported as papillary thyroid cancer (P...

BackgroundArtificial intelligence algorithms can be used in classification of thyroid nodules to reduce subjectivity. External validation on images collected from different ultrasound machines and other institutions are vital before wider use of these algorithms. We retrospectively analyzed the performance of AIBx on thyroid nodules with surgically proven pathology.Materials and methodsPatients harboring thyr...

ObjectiveThe objective of this systematic review was to assess the proportion of patients with prolactinomas that obtain remission or experience adverse effects after transsphenoidal surgery.DesignA systematic review. Registered at PROSPERO, registration number CRD42020213002MethodsA bibliographical search of PubMed and Embase was performed and last updated on Sep...

IntroductionLangherans Cell Histiocytosis (LCH) is a rare disease due to a neoplastic proliferation of Langerhans-type cells. Hypothalamic-pituitary (HP) involvement may occur in 20–40% of the patients, presenting with diabetes insipidus (DI) and/or anterior pituitary dysfunction. Typically, such abnormalities are permanent and unresponsive to systemic treatment of LCH. We report the case of a young woman with pulmonary and HP localizations, and sig...

Objective: As a measure to reduce overtreatment, active surveillance (AS) for low-risk papillary thyroid carcinoma (PTC) has spread from Japan and gradually become accepted around the world. Older age is known to be a favorable factor for progression under AS; however, long-term evidence is still limited and lifelong monitoring is considered inevitable. The present study reviewed the results of AS from the 1990s and explored the possibility of completing follow-up.<p class...

Objectives: Active surveillance (AS) for low-risk papillary thyroid carcinoma (PTC) has been adopted as a reasonable approach to management worldwide. In our previous cross-sectional study, patients who chose AS had better mental patient-reported outcomes (PRO) compared to those who underwent immediate surgery. This prospective, longitudinal study aimed to compare PROs between patients who chose AS and those who underwent surgery, during a one-year follow-up from the time of d...

Obesity rate keeps growing worldwide and weighs heavily on the healthcare system because of the related metabolic disorders like diabetes. In addition to calorie-rich diet and sedentary lifestyle, environmental exposure to obesogens, endocrine disrupting chemicals (EDC) targeting adipose tissue and its function as well as central pathways regulating food intake and energy expenditure, could add to the raising obesity incidence. The flame-retardant tetrabromobisphenol A (TBBPA)...